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1. To treat a sacred place or thing with violent disrespect; to violate
2. To spoil or damage something that is respected or admired
1. The villainous Thanos desecrated the hallowed halls of Asgard seeking the Infinity Stones.
2. In a comedic turn of events, Doraemon's gadget malfunctioned and desecrated Nobita's homework, much to his dismay.
3. The corrupt businessman planned to desecrate the ancient forest to build a new shopping mall, but Wonder Woman intervened to protect it.
4. When the Joker desecrated the art museum with his graffiti, Batman was quick to restore order to Gotham City.