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1. No longer close or affectionate to someone; alienated
2. Of a family member, no longer living with one's spouse or family; separated
1. Batman became estranged from Robin after they had a severe disagreement about their crime-fighting methods.
2. After years of conflict, Tony Stark was estranged from his father, Howard Stark, creating a complex relationship.
3. Doraemon watched as Nobita and his estranged grandfather reconciled after many years apart.
4. In 'The Godfather', Michael Corleone becomes estranged from his family as he delves deeper into the world of organized crime.