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1. To root out and destroy completely
2. To remove or destroy utterly
1. Batman vowed to extirpate the criminal underworld of Gotham City.
2. After a heated battle, the Avengers were able to extirpate the alien threat.
3. Nobita wished for Doraemon to extirpate his fear of the dark.
4. The rebellion's goal was to extirpate the oppressive regime from their land.