| salubrious | Health-giving; healthy | |
| salutary | producing a beneficial effect; promoting health | |
| sangfroid | Composure or coolness shown in danger or under trying circumstances | |
| sanguine | Optimistic or positive, especially in an apparently bad or difficult situation | |
| sapid | Having a strong, pleasant taste | |
| sapient | Having great wisdom or discernment | |
| sardonic | Characterized by bitter or scornful derision; mocking; cynical; sneering | |
| scanty | Small or insufficient in quantity or amount | |
| scathing | witheringly scornful; severely critical | |
| schadenfreude | Pleasure derived by someone from another person's misfortune | |