| splenetic | Bad-tempered; spiteful | |
| spurious | Not being what it purports to be; false or fake | |
| squalid | Extremely dirty and unpleasant, especially as a result of poverty or neglect | |
| squelch | To forcefully silence or suppress someone or something | |
| stalwart | Loyal, reliable, and hardworking | |
| stanch | To stop the flow of blood or other liquid | |
| staple | A basic or principal element or feature | |
| statuesque | Attractively tall and dignified, especially in a woman | |
| stigmas | Marks of disgrace associated with a particular circumstance, quality, or person | |
| stilted | Speech or writing that is stiff and self-conscious, not natural or fluent | |