| slovenly | Messy or untidy in appearance or habits | |
| slipshod | Characterized by a lack of care, thought, or organization | |
| slatternly | Untidy and dirty through habitual neglect; carelessly slovenly | |
| slander | The action or crime of making a false spoken statement damaging to a person's reputation | |
| slake | To satisfy (a craving or desire), quench | |
| skulk | To move stealthily or furtively | |
| skulduggery | Dishonest or unscrupulous behavior or activity; underhanded dealings | |
| sinuous | Having many curves and turns | |
| simulacrum | An image or representation of someone or something | |
| simper | To smile in a silly, self-conscious, often coy manner | |