| scotch | To put an end to; to prevent; to decisively defeat or terminate | |
| scofflaw | A person who flouts the law, especially one who fails to pay fines owed | |
| sclerotic | Relating to or having sclerosis, an abnormal hardening of body tissue | |
| scintillating | Sparkling or shining brightly | |
| schism | A split or division between strongly opposed sections or parties, caused by differences in opinion or belief | |
| schadenfreude | Pleasure derived by someone from another person's misfortune | |
| scathing | witheringly scornful; severely critical | |
| scanty | Small or insufficient in quantity or amount | |
| sardonic | Characterized by bitter or scornful derision; mocking; cynical; sneering | |
| sapient | Having great wisdom or discernment | |